10.7554/eLife.80729.1 The role of adolescent lifestyle habits in biological aging: A prospective twin study
10.7554/eLife.84355.1 Transcriptional regulation and repressive condensates modulate a proliferative-invasive cellular switch in vivo
10.7554/eLife.80984.1 The circadian clock controls temporal and spatial patterns of floral development in sunflower
10.7554/eLife.84628.1 The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
10.7554/eLife.84427.1 Structural foundation for the role of enterococcal PrgB in conjugation, biofilm formation and virulence
10.7554/eLife.84921.1 Surface curvature and basal hydraulic stress induce spatial bias in cell extrusion
10.7554/eLife.84792.1 Precision RNAi using synthetic shRNAmir target sites
10.7554/eLife.86722.1 Rapid, DNA-induced subunit exchange by DNA gyrase
10.7554/eLife.85875.1 Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response
10.7554/eLife.84364.1 Opto-RhoGEFs: an optimized optogenetic toolbox to reversibly control Rho GTPase activity on a global to subcellular scale, enabling precise control over vascular endothelial barrier strength
10.7554/eLife.81535.1 Optogenetic induction of appetitive and aversive taste memories in Drosophila
10.7554/eLife.85646.1 Parahippocampal neurons encode task-relevant information for goal-directed navigation
10.7554/eLife.84385.1 Neuroelectrophysiology-Compatible Electrolytic Lesioning
10.7554/eLife.86633.1 Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling
10.7554/eLife.84553.1 Non-invasive real-time genomic monitoring of the critically endangered kākāpō
10.7554/eLife.86628.1 Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution
10.7554/eLife.85069.1 Mega-scale movie-fields in the mouse visuo-hippocampal network
10.7554/eLife.84747.1 Mimicking genuine drought responses using a high throughput plate assay
10.7554/eLife.86636.1 Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission
10.7554/eLife.86972.1 Importance of Glutamine in Synaptic Vesicles Revealed by Functional Studies of SLC6A17 and Its Mutations Pathogenic for Intellectual Disability
10.7554/eLife.84926.1 Inhibition drives habituation of a larval zebrafish visual response
10.7554/eLife.84570.1 Inhibition of Type I PRMTs Reforms Muscle Stem Cell Identity Enhancing their Therapeutic Capacity
10.7554/eLife.85596.1 Identification of Candidate Mitochondrial Inheritance Determinants Using the Mammalian Cell-Free System
10.7554/eLife.85380.1 FOXC2 marks and maintains the primitive spermatogonial stem cells subpopulation in the adult testis
10.7554/eLife.84338.1 FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD
10.7554/eLife.81926.1 Hepatic lipid overload potentiates biliary epithelial cell activation via E2Fs
10.7554/eLife.84831.1 High-Throughput Library Transgenesis in Caenorhabditis elegans via Transgenic Arrays Resulting in Diversity of Integrated Sequences (TARDIS)
10.7554/eLife.84141.1 Endotaxis: A neuromorphic algorithm for mapping, goal-learning, navigation, and patrolling
10.7554/eLife.84874.1 Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations
10.7554/eLife.86100.1 Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human
10.7554/eLife.86663.1 Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization
10.7554/eLife.84630.1 Cortico-thalamo-cortical interactions modulate electrically evoked EEG responses in mice
10.7554/eLife.84537.1 Behavioral dissection of hunger states in Drosophila
10.7554/eLife.84918.1 Competition between myosin II and βH-Spectrin regulates cytoskeletal tension
10.7554/eLife.81727.1 Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain
10.7554/eLife.84855.1 Analysis of science journalism reveals gender and regional disparities in coverage
10.7554/eLife.85654.1 Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma
10.7554/eLife.86776.1 Autoinhibited kinesin-1 adopts a hierarchical folding pattern
10.7554/eLife.80494.1 Aging-related iron deposit prevents the benefits of HRT from late postmenopausal atherosclerosis
10.7554/eLife.86591.1 An Unexpected Role of Neutrophils in Clearing Apoptotic Hepatocytes In Vivo
10.7554/eLife.86699.1 A simple mechanism for integration of quorum sensing and cAMP signalling in V. cholerae
10.7554/eLife.84604.1 A stable, distributed code for cue value in mouse cortex during reward learning
10.7554/eLife.87038.1 A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes
10.7554/eLife.85760.1 A descending inhibitory mechanism of nociception mediated by an evolutionarily conserved neuropeptide system in Drosophila
10.7554/eLife.88799.1 Distinct states of nucleolar stress induced by anti-cancer drugs
10.7554/eLife.88955.2 Absence of electron transfer-associated changes in the time-dependent X-ray free-electron laser structures of the photosynthetic reaction center
10.7554/eLife.88652.1 The canonical stopping network: Revisiting the role of the subcortex in response inhibition
10.7554/eLife.87736.1 Running modulates primate and rodent visual cortex differently
10.7554/eLife.88744.1 miR-252 targeting temperature receptor CcTRPM to mediate the transition from summer-form to winter-form of Cacopsylla chinensis
10.7554/eLife.87881.1 Revealing unexpected complex encoding but simple decoding mechanisms in motor cortex via separating behaviorally relevant neural signals
10.7554/eLife.89267.1 Optogenetic stimulation of the locus coeruleus enhances appetitive extinction in rats
10.7554/eLife.89489.1 Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states
10.7554/eLife.88638.1 Ryanodine receptor 2 inhibition improves cardiac repolarization reserve and contractile function and prevents sudden arrhythmic death in failing hearts
10.7554/eLife.88866.1 The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival
10.7554/eLife.86852.1 Influenza virus transcription and progeny production are poorly correlated in single cells
10.7554/eLife.89167.1 Mechanism of substrate binding and transport in BASS transporters
10.7554/eLife.88737.1 Epistasis facilitates functional evolution in an ancient transcription factor
10.7554/eLife.88960.1 Molecular mechanism of complement inhibition by the trypanosome receptor ISG65
10.7554/eLife.87749.1 Delayed postglacial colonization of Betula in Iceland and the circum North Atlantic
10.7554/eLife.88863.1 Leveraging genetic correlation structure to target discrete signaling mechanisms across metabolic tissues
10.7554/eLife.86324.2 Transposons are important contributors to gene expression variability under selection in rice populations
10.7554/eLife.88670.1 I-Spin live: An open-source software based on blind-source separation for decoding the activity of spinal alpha motor neurons in real-time
10.7554/eLife.88919.1 Functional ultrasound imaging of stroke in awake rats
10.7554/eLife.88348.1 Recursive self-embedded vocal motifs in wild orangutans
10.7554/eLife.86988.1 Intra and interspecific diversity in a tropical plant clade alter herbivory and ecosystem resilience
10.7554/eLife.88551.1 Myomatrix arrays for high-definition muscle recording
10.7554/eLife.88619.1 SNAP25 disease mutations change the energy landscape for synaptic exocytosis due to aberrant SNARE interactions
10.7554/eLife.88318.1 DYRK1A Interacts with the Tuberous Sclerosis Complex and Promotes mTORC1 Activity
10.7554/eLife.89106.1 Evidence for deliberate burial of the dead by Homo naledi
10.7554/eLife.87634.1 Hippocampal subfield CA1-3 shows differential structural and functional network plasticity after stress-reducing socio-affective mental training
10.7554/eLife.89102.1 241,000 to 335,000 Years Old Rock Engravings Made by Homo naledi in the Rising Star Cave system, South Africa
10.7554/eLife.89050.1 Automated cell annotation in multi-cell images using an improved CRF_ID algorithm
10.7554/eLife.88540.1 Trends in self-citation rates in Neuroscience literature
10.7554/eLife.85597.2 Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor
10.7554/eLife.89125.1 Burials and engravings in a small-brained hominin, Homo naledi, from the late Pleistocene: contexts and evolutionary implications
10.7554/eLife.88523.1 C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy
10.7554/eLife.86913.2 Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer
10.7554/eLife.86635.2 Adolescent length growth spurts in bonobos and other primates: Mind the scale
10.7554/eLife.88414.1 Spatial Transcriptomics of Meningeal Inflammation Reveals Variable Penetrance of Inflammatory Gene Signatures into Adjacent Brain Parenchyma
10.7554/eLife.87928.1 Whole-genomes from the extinct Xerces Blue butterfly can help identify declining insect species
10.7554/eLife.86678.1 Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis
10.7554/eLife.88279.1 Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
10.7554/eLife.88567.1 Alterations in cortical excitability during pain: A combined TMS-EEG Study
10.7554/eLife.88024.1 ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse
10.7554/eLife.87930.1 De novo identification of universal cell mechanics gene signatures
10.7554/eLife.88733.1 Periaqueductal gray activates antipredatory neural responses in the amygdala of foraging rats
10.7554/eLife.88521.1 BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism
10.7554/eLife.86191.1 Dietary Restriction Impacts Peripheral Circadian Clock Output Important for Longevity in Drosophila
10.7554/eLife.88468.1 A statistical framework for quantifying the nuclear export rate of influenza viral mRNAs
10.7554/eLife.88900.1 Molecular tuning of sea anemone stinging
10.7554/eLife.88275.1 Hematopoietic Transfer of the Anti-Cancer and Lifespan-Extending Capabilities of A Genetically Engineered Blood System
10.7554/eLife.89232.1 Mitochondrial temperature homeostasis resists external metabolic stresses
10.7554/eLife.87616.2 Structure of the connexin-43 gap junction channel in a putative closed state
10.7554/eLife.87714.2 Histone variants shape chromatin states in Arabidopsis
10.7554/eLife.88782.1 FMRP regulates neuronal migration via MAP1B
10.7554/eLife.89093.1 Reward contingency gates selective cholinergic suppression of amygdala neurons
10.7554/eLife.89371.1 DNA methylation-environment interactions in the human genome
10.7554/eLife.87238.1 Effort cost of harvest affects decisions and movement vigor of marmosets during foraging
10.7554/eLife.88874.1 Sustained store-operated calcium entry utilizes activated chromatin state leads to instability in iTregs
10.7554/eLife.87991.1 The integration of Tgfβ and Egfr signaling programs confers the ability to lead heterogeneous collective invasion
10.7554/eLife.87369.1 A Large-Scale Proteomics Resource of Circulating Extracellular Vesicles for Biomarker Discovery in Pancreatic Cancer
10.7554/eLife.88247.1 Octopamine integrates the status of internal energy supply into the formation of food-related memories
10.7554/eLife.87016.1 Wandering albatross exert high take-off effort in weak wind with low wave conditions
10.7554/eLife.89459.1 Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting
10.7554/eLife.88256.1 PITAR, a DNA damage-inducible Cancer/Testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA
10.7554/eLife.88420.1 Comparative Whole-Brain Mapping of Isoflurane and Ketamine-Activated Nuclei and Functional Networks
10.7554/eLife.88359.1 Sleep Regularity and Mortality: A Prospective Analysis in the UK Biobank
10.7554/eLife.89045.1 Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis
10.7554/eLife.88222.1 Imputation of 3D genome structure by genetic-epigenetic interaction modeling in mice
10.7554/eLife.87611.1 A Vibrio cholerae viral satellite maximizes its spread and inhibits phage by remodeling hijacked phage coat proteins into small capsids
10.7554/eLife.88984.1 Analysis of NIH K99/R00 Awards and the Career Progression of Awardees
10.7554/eLife.88403.1 Free energy landscapes of KcsA inactivation
10.7554/eLife.87569.2 Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population
10.7554/eLife.87668.1 Conserving bird populations in the Anthropocene: the significance of non-breeding movements
10.7554/eLife.88565.1 Delta-dependent Notch activation closes the early neuroblast temporal program to promote lineage progression and neurogenesis termination in Drosophila
10.7554/eLife.86670.3 Transcriptomic profiling of tissue environments critical for post-embryonic patterning and morphogenesis of zebrafish skin
10.7554/eLife.87966.1 Free volume theory explains the unusual behavior of viscosity in a non-confluent tissue during morphogenesis
10.7554/eLife.88087.1 Identification of 1600 replication origins in S. cerevisiae
10.7554/eLife.86687.2 Gene expression plasticity followed by genetic change during colonization a high-elevation environment
10.7554/eLife.88604.1 Repeatability of adaptation in sunflowers: genomic regions harbouring inversions also drive adaptation in species lacking an inversion
10.7554/eLife.88772.1 Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey bee Apis mellifera
10.7554/eLife.85875.2 Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response
10.7554/eLife.88404.1 Evaluation of surface-based hippocampal registration using ground-truth subfield definitions
10.7554/eLife.85596.2 Identification of Candidate Mitochondrial Inheritance Determinants Using the Mammalian Cell-Free System
10.7554/eLife.88367.1 Event-related modulation of alpha rhythm explains the auditory P300 evoked response in EEG
10.7554/eLife.85380.2 Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals
10.7554/eLife.88221.1 Intrinsic protein disorder is insufficient to drive subnuclear clustering in embryonic transcription factors
10.7554/eLife.88971.1 Transposon mutagenesis screen in Klebsiella pneumoniae identifies genetic determinants required for growth in human urine and serum
10.7554/eLife.89054.1 Broca’s area, variation and taxic diversity in early Homo from Koobi Fora (Kenya)
10.7554/eLife.88172.1 Network-Level Changes in the Brain Underlie Fear Memory Strength
10.7554/eLife.87780.1 Linking the evolution of two prefrontal brain regions to social and foraging challenges in primates
10.7554/eLife.88253.1 Natural variation in the Caenorhabditis elegans egg-laying circuit modulates an intergenerational fitness trade-off
10.7554/eLife.86655.1 Molecular portraits of colorectal cancer morphological regions
10.7554/eLife.88657.1 Sensory neurons couple arousal and foraging decisions in C. elegans
10.7554/eLife.87719.1 A computationally informed comparison between the strategies of humans and rodents in visual object recognition
10.7554/eLife.88538.1 Association between APOL1 risk variants and progression from infection to sepsis
10.7554/eLife.87993.1 SIRT-1 is required for release of enveloped picornaviruses
10.7554/eLife.87078.1 Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice
10.7554/eLife.88122.1 Ebola Virus Sequesters IRF3 in Viral Inclusion Bodies to Evade Host Antiviral Immunity
10.7554/eLife.86633.2 Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling
10.7554/eLife.84918.2 Competition between myosin II and βH-Spectrin regulates cytoskeletal tension
10.7554/eLife.88082.1 Zn2+ is Essential for Ca2+ Oscillations in Mouse Eggs
10.7554/eLife.87880.1 Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy
10.7554/eLife.88659.1 Computational analysis of long-range allosteric communications in CFTR
10.7554/eLife.88366.1 Genetic and karyotype divergence between parents affect clonality and sterility in hybrids
10.7554/eLife.88995.1 Developmental Alterations in Brain Network Asymmetry in 3- to 9-Month Infants with Congenital Sensorineural Hearing Loss
10.7554/eLife.88398.1 Separating phases of allopolyploid evolution with resynthesized and natural Capsella bursa-pastoris
10.7554/eLife.87356.1 A dynamical computational model of theta generation in hippocampal circuits to study theta-gamma oscillations during neurostimulation
10.7554/eLife.87346.1 Action-sequence learning, habits and automaticity in obsessive-compulsive disorder
10.7554/eLife.88810.1 Rats emit aversive 44-kHz ultrasonic vocalizations during prolonged Pavlovian fear conditioning
10.7554/eLife.88065.1 TCR-pMHC complex formation triggers CD3 dynamics
10.7554/eLife.88591.1 MotorNet: a Python toolbox for controlling differentiable biomechanical effectors with artificial neural networks
10.7554/eLife.89049.1 Prior information enhances tactile representation in primary somatosensory cortex
10.7554/eLife.87039.2 Linking genotypic and phenotypic changes in the E. coli Long-Term Evolution Experiment using metabolomics
10.7554/eLife.86591.2 An Unexpected Role of Neutrophils in Clearing Apoptotic Hepatocytes In Vivo
10.7554/eLife.87197.1 Human Attention during Goal-directed Reading Comprehension Relies on Task Optimization
10.7554/eLife.87529.1 Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making
10.7554/eLife.87462.1 High-precision mapping of nuclear pore-chromatin interactions reveals new principles of genome organization at the nuclear envelope
10.7554/eLife.86827.1 A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia via MEK-ERK-FOSL1 axis
10.7554/eLife.88237.1 Nuclear bodies protect phase separated proteins from degradation in stressed proteome
10.7554/eLife.87589.1 Astrocytic Neuroligins Are Not Required for Synapse Formation or a Normal Astrocyte Cytoarchitecture
10.7554/eLife.87607.1 Long-read single-cell sequencing reveals expressions of hypermutation clusters of isoforms in human liver cancer cells
10.7554/eLife.87985.1 Exploring the K+ binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT
10.7554/eLife.87747.1 The ability to sense the environment is heterogeneously distributed in cell populations
10.7554/eLife.87753.1 GABAergic synaptic scaling is triggered by changes in spiking activity rather than transmitter receptor activation
10.7554/eLife.87147.2 Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms
10.7554/eLife.88124.1 Thalamic regulation of ocular dominance plasticity in adult visual cortex
10.7554/eLife.88991.1 Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases
10.7554/eLife.87075.1 Distinct hippocampal and cortical contributions in the representation of hierarchies
10.7554/eLife.87696.2 Rubella virus tropism and single cell responses in human primary tissue and microglia-containing organoids
10.7554/eLife.88459.1 Deciphering Neuronal Deficit and Protein Profile Changes in Human Brain Organoids from Patients with Creatine Transporter Deficiency
10.7554/eLife.87884.1 Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16
10.7554/eLife.88008.1 Vertical transmission of maternal mitochondrial DNA through extracellular vesicles modulates embryo bioenergetics
10.7554/eLife.87922.1 A novel cell division protein critical for the assembly of the bacterial divisome
10.7554/eLife.87833.1 N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters
10.7554/eLife.86360.1 Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development
10.7554/eLife.88212.1 Parallel processing of quickly and slowly mobilized reserve vesicles in hippocampal synapses
10.7554/eLife.87811.1 A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence
10.7554/eLife.88982.1 An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor
10.7554/eLife.87330.1 A new look at the architecture and dynamics of the Hydra nerve net
10.7554/eLife.84792.2 Precision RNAi using synthetic shRNAmir target sites
10.7554/eLife.87522.1 Sibling Similarity Can Reveal Key Insights Into Genetic Architecture
10.7554/eLife.84338.2 FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD
10.7554/eLife.87465.1 Is tumor mutational burden predictive of response to immunotherapy?
10.7554/eLife.87198.1 Chromosome-level genome assembly of hadal snailfish reveals mechanisms of deep-sea adaptation in vertebrates
10.7554/eLife.87431.1 Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells
10.7554/eLife.86891.1 Alternative paths to immune activation: the role of costimulatory risk genes for polygenic inflammatory disease in T helper cells
10.7554/eLife.87174.1 Diameter Dependence of Transport through Nuclear Pore Complex Mimics Studied Using Optical Nanopores
10.7554/eLife.87419.1 Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
10.7554/eLife.87258.1 A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury
10.7554/eLife.88608.1 Differentiation and Integration of Competing Memories: A Neural Network Model
10.7554/eLife.88198.1 Experimentally induced active and quiet sleep engage non-overlapping transcriptomes in Drosophila
10.7554/eLife.86636.2 Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission
10.7554/eLife.87030.1 Anti-inflammatory therapy with nebulised dornase alfa in patients with severe COVID-19 pneumonia A Randomised Clinical Trial
10.7554/eLife.88207.1 Cell type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis
10.7554/eLife.87754.1 β-arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor
10.7554/eLife.86576.1 100 years of anthropogenic impact causes changes in freshwater functional biodiversity
10.7554/eLife.87083.1 Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis
10.7554/eLife.88189.1 Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations
10.7554/eLife.88656.1 What AlphaFold tells us about cohesin’s retention on and release from chromosomes
10.7554/eLife.87895.1 How microscopic epistasis and clonal interference shape the fitness trajectory in a spin glass model of microbial long-term evolution
10.7554/eLife.88143.1 Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion
10.7554/eLife.84364.2 Opto-RhoGEFs: an optimized optogenetic toolbox to reversibly control Rho GTPase activity on a global to subcellular scale, enabling precise control over vascular endothelial barrier strength
10.7554/eLife.87037.2 Reciprocal discoidin domain receptor signaling strengthens integrin adhesion to connect adjacent tissues
10.7554/eLife.88058.2 Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
10.7554/eLife.86939.1 Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal
10.7554/eLife.88117.1 Gene-Environment Pathways to Cognitive Development and Psychotic-Like Experiences in Children
10.7554/eLife.88205.1 Do glucocorticoids indicate stress? Meta-analysis reveals a tight association between glucocorticoids and metabolic rate
10.7554/eLife.88319.1 The cation channel mechanisms of subthreshold inward depolarizing currents in the VTA dopaminergic neurons and their roles in the depression-like behavior
10.7554/eLife.87912.1 A dual function of the IDA peptide in regulating cell separation and modulating plant immunity at the molecular level
10.7554/eLife.86638.1 Energetics of the Microsporidian Polar Tube Invasion Machinery
10.7554/eLife.84630.2 Cortico-thalamo-cortical interactions modulate electrically evoked EEG responses in mice
10.7554/eLife.87644.1 Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection
10.7554/eLife.87196.1 Structure of the photosynthetic Calvin-Benson-Bassham sedoheptulose-1,7-bisphosphatase SBPase from the model microalga Chlamydomonas reinhardtii
10.7554/eLife.87698.1 Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function
10.7554/eLife.87720.1 Approach-avoidance reinforcement learning as a translational and computational model of anxiety-related avoidance
10.7554/eLife.86791.1 Microplastics are present in women’s and cows’ follicular fluid and polystyrene microplastics compromise bovine oocyte function in vitro
10.7554/eLife.87730.1 Comprehensive mutagenesis maps the effect of all single codon mutations in the AAV2 rep gene on AAV production
10.7554/eLife.84604.2 A stable, distributed code for cue value in mouse cortex during reward learning
10.7554/eLife.88273.1 Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development
10.7554/eLife.86699.2 A simple mechanism for integration of quorum sensing and cAMP signalling in V. cholerae
10.7554/eLife.84831.2 High-Throughput Library Transgenesis in Caenorhabditis elegans via Transgenic Arrays Resulting in Diversity of Integrated Sequences (TARDIS)
10.7554/eLife.87288.1 Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis
10.7554/eLife.87726.1 A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture
10.7554/eLife.87217.1 Hippocampal remapping induced by new behavior is mediated by spatial context
10.7554/eLife.87151.1 σ28-dependent small RNA regulation of flagella biosynthesis
10.7554/eLife.88084.1 Structural rather than catalytic role for mitochondrial respiratory chain supercomplexes
10.7554/eLife.88132.1 Plant Arbovirus Mobilizes a Vector Salivary Protein to Initiate Plant Infection
10.7554/eLife.88614.1 Pharyngeal Mechanosensory Neurons Control Food Swallow in Drosophila melanogaster
10.7554/eLife.87866.1 Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing
10.7554/eLife.88053.1 Drift of neural ensembles driven by slow fluctuations of intrinsic excitability
10.7554/eLife.85795.2 Temperature sensitivity of the interspecific interaction strength of coastal marine fish communities
10.7554/eLife.88135.1 RBP-J regulates homeostasis and function of circulating Ly6Clo monocytes
10.7554/eLife.87739.1 A versatile high-throughput assay based on 3D ring-shaped cardiac tissues generated from human induced pluripotent stem cell derived cardiomyocytes
10.7554/eLife.86944.1 Loss of PTPMT1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure
10.7554/eLife.87458.1 Microbially-derived indole-3-acetate alleviates diet induced steatosis and inflammation in mice
10.7554/eLife.88144.1 Bias in FGFR1 signaling in response to FGF4, FGF8, and FGF9
10.7554/eLife.87742.1 SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state
10.7554/eLife.86764.1 Murine Alveolar Macrophages Rapidly Accumulate Intranasally Administered SARS-CoV-2 Spike Protein leading to Neutrophil Recruitment and Damage
10.7554/eLife.86978.1 Establishing And Maintaining The Blood-Brain Barrier: Epigenetic And Signaling Determinants
10.7554/eLife.88268.1 A Timeline of Bacterial and Archaeal Diversification in the Ocean
10.7554/eLife.87316.1 Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in ESRD
10.7554/eLife.88456.1 The molecular clock in long-lived tropical trees is independent of growth rate
10.7554/eLife.88054.1 Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response
10.7554/eLife.88138.1 Activation of the P2RX7/IL-18 pathway in immune cells attenuates lung fibrosis
10.7554/eLife.87430.1 β-carotene accelerates resolution of atherosclerosis by promoting regulatory T cell expansion in the atherosclerotic lesion
10.7554/eLife.88491.1 High-throughput Automated Muropeptide Analysis (HAMA) Reveals Peptidoglycan Composition of Gut Microbial Cell Walls
10.7554/eLife.86833.1 Diminishing neuronal acidification by channelrhodopsins with low proton conduction
10.7554/eLife.88658.1 Hsf1 and the molecular chaperone Hsp90 support a “rewiring stress response” leading to an adaptive cell size increase in chronic stress
10.7554/eLife.87317.1 Intuitive movement-based prosthesis control enables arm amputees to reach naturally in virtual reality
10.7554/eLife.87306.1 Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons
10.7554/eLife.88183.1 Mouse gingival single-cell transcriptomic atlas: An activated fibroblast subpopulation guides oral barrier immunity in periodontitis
10.7554/eLife.86721.1 Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases
10.7554/eLife.87120.1 A rapid microglial metabolic response controls metabolism and improves memory
10.7554/eLife.87536.1 De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness
10.7554/eLife.87989.1 Binding to nucleosome poises SIRT6 for histone H3 de-acetylation
10.7554/eLife.87518.1 Metabolic regulation of misfolded protein import into mitochondria
10.7554/eLife.86668.1 Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis
10.7554/eLife.88483.1 Integrin β4 promotes DNA damage drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/Rac1
10.7554/eLife.88289.1 Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo
10.7554/eLife.87602.1 Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila
10.7554/eLife.87860.1 The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles
10.7554/eLife.87022.1 Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision making
10.7554/eLife.88488.1 Adenylnucleotide-mediated binding of the PII-like protein SbtB contributes to controlling activity of the cyanobacterial bicarbonate transporter SbtA
10.7554/eLife.84537.2 Behavioral dissection of hunger states in Drosophila
10.7554/eLife.88579.1 Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space
10.7554/eLife.87026.2 Extensive re-modelling of the cell wall during the development of Staphylococcus aureus bacteraemia
10.7554/eLife.87414.1 Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function
10.7554/eLife.88057.1 Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age
10.7554/eLife.87729.1 A generative model of electrophysiological brain responses to stimulation
10.7554/eLife.88229.1 Broad functional profiling of fission yeast proteins using phenomics and machine learning
10.7554/eLife.87958.1 Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases
10.7554/eLife.88317.1 Coordinated regulation of gene expression in Plasmodium female gametocytes by two transcription factors
10.7554/eLife.88623.1 voyAGEr: free web interface for the analysis of age-related gene expression alterations in human tissues
10.7554/eLife.88261.1 The scheduling of adolescence with Netrin-1 and UNC5C
10.7554/eLife.87756.1 Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
10.7554/eLife.88299.1 Mechanism of stepwise electron transfer in six-transmembrane epithelial antigen of the prostate (STEAP) 1 and 2
10.7554/eLife.87133.1 GENIUS: GEnome traNsformatIon and spatial representation of mUltiomicS data
10.7554/eLife.86169.1 Glutaredoxin regulation of primary root growth confers early drought stress tolerance in pearl millet
10.7554/eLife.87559.1 Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development
10.7554/eLife.87651.1 Dissecting muscle synergies in the task space
10.7554/eLife.87691.1 Mesotrode: chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice
10.7554/eLife.86975.1 FKBP35 secures ribosome homeostasis in Plasmodium falciparum
10.7554/eLife.86996.1 Maternal group 2 innate lymphoid cells contribute to fetal growth and protection from endotoxin-induced abortion in mice
10.7554/eLife.87572.1 Replisome loading reduces chromatin motion independent of DNA synthesis
10.7554/eLife.87528.1 Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by Atf4 following optic nerve injury
10.7554/eLife.86933.1 Transcriptional Cartography Integrates Multiscale Biology of the Human Cortex
10.7554/eLife.87361.1 Viral genome sequence datasets display pervasive evidence of strand-specific substitution biases that are best described using non-reversible nucleotide substitution models
10.7554/eLife.86687.1 Gene expression plasticity followed by genetic change during colonization a high-elevation environment
10.7554/eLife.87303.1 Light inducible protein degradation in E. coli with LOVtag
10.7554/eLife.87406.1 Bactabolize: A tool for high-throughput generation of bacterial strain-specific metabolic models
10.7554/eLife.87368.1 Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis
10.7554/eLife.87523.1 An important role for triglyceride in regulating spermatogenesis
10.7554/eLife.87178.2 Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange
10.7554/eLife.87005.1 Multiple repeat regions within mouse DUX recruit chromatin regulators to facilitate an embryonic gene expression program
10.7554/eLife.87674.1 Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis
10.7554/eLife.87672.1 Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ
10.7554/eLife.87192.1 Bacterial DNA on the skin surface overrepresents the viable skin microbiome
10.7554/eLife.86903.1 A randomized multiplex CRISPRi-Seq approach for the identification of critical combinations of genes
10.7554/eLife.87956.1 Inositol pyrophosphate dynamics reveals control of the yeast PHO starvation program through 1,5-IP8 and the SPX domain of Pho81
10.7554/eLife.87055.1 Firing rate adaptation affords place cell theta sweeps, phase precession and procession
10.7554/eLife.86820.1 Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking
10.7554/eLife.87252.1 Cerebellar Activation Bidirectionally Regulates Nucleus Accumbens Core and Medial Shell
10.7554/eLife.87714.1 Histone variants shape the chromatin states in Arabidopsis
10.7554/eLife.87569.1 Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population
10.7554/eLife.86837.1 A Theory of Hippocampal Theta Correlations
10.7554/eLife.85786.1 Pynapple: a toolbox for data analysis in neuroscience
10.7554/eLife.87965.1 Inhibitory CCK+ basket synapse defects in mouse models of dystroglycanopathy
10.7554/eLife.86628.2 Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution
10.7554/eLife.87445.1 Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
10.7554/eLife.86931.1 Mycolactone causes catastrophic Sec61-dependent loss of the endothelial glycocalyx and basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection
10.7554/eLife.87297.1 The (Limited?) Utility of Brain Age as a Biomarker for Capturing Cognitive Decline
10.7554/eLife.87386.1 The acetylase activity of Cdu1 protects Chlamydia effectors from degradation to regulate bacterial exit from infected cells
10.7554/eLife.86194.1 Impairment of lipid homoeostasis causes accumulation of protein aggregates in the lysosome
10.7554/eLife.87065.1 Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp
10.7554/eLife.87935.1 Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation
10.7554/eLife.86843.1 Substrate evaporation drives collective construction in termites
10.7554/eLife.87455.1 Epistasis supports viability under extensive gene-dose insufficiency following chromosome loss
10.7554/eLife.87037.1 Reciprocal discoidin domain receptor signaling strengthens integrin adhesion to connect adjacent tissues
10.7554/eLife.87527.1 Dendritic growth and synaptic organization from activity-independent cues and local activity-dependent plasticity
10.7554/eLife.86920.1 Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins
10.7554/eLife.86695.1 A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster
10.7554/eLife.87515.1 Molecular Consequences of Peripheral Influenza A Infection on Cell Populations in the Murine Hypothalamus
10.7554/eLife.87283.1 A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression
10.7554/eLife.86961.1 Leveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance
10.7554/eLife.88049.1 Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity
10.7554/eLife.86940.1 The differentiation and integration of the hippocampal dorsoventral axis are controlled by two nuclear receptor genes
10.7554/eLife.87468.1 Structural and mechanistic insights into the MCM8/9 helicase complex
10.7554/eLife.86740.1 Adaptive biasing of action-selective cortical build-up activity by choice history
10.7554/eLife.85111.2 The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity
10.7554/eLife.87126.1 Conflicts are represented in a cognitive space to reconcile domain-general and domain-specific cognitive control
10.7554/eLife.87521.1 The zebrafish mutant dreammist implicates sodium homeostasis in sleep regulation
10.7554/eLife.87048.1 Different rules for binocular combination of luminance flicker in cortical and subcortical pathways
10.7554/eLife.86805.1 Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers
10.7554/eLife.86749.1 Imaging Microglia Surveillance during Sleep-wake Cycles in Freely Behaving Mice
10.7554/eLife.86943.1 Remapping in a recurrent neural network model of navigation and context inference
10.7554/eLife.86913.1 Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer
10.7554/eLife.87188.1 Age-related differences in the functional topography of the locus coeruleus: implications for cognitive and affective functions
10.7554/eLife.86324.1 Transposons are a major contributor to gene expression variability under selection in rice populations
10.7554/eLife.85921.1 RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy
10.7554/eLife.87510.1 A positive feedback loop between ZEB2 and ACSL4 regulates lipid metabolism to promote breast cancer metastasis
10.7554/eLife.86892.1 Judging the difficulty of perceptual decisions
10.7554/eLife.87434.1 Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation
10.7554/eLife.87008.1 Higher social tolerance is associated with more complex facial behavior in macaques
10.7554/eLife.86990.1 Control of telomere length in yeast by SUMOylated PCNA and the Elg1 PCNA unloader
10.7554/eLife.87340.1 Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle
10.7554/eLife.87115.1 Microhomology-Mediated Circular DNA Formation from Oligonucleosomal Fragments During Spermatogenesis
10.7554/eLife.87099.1 Gene regulatory patterning codes in early cell fate specification of the C. elegans embryo
10.7554/eLife.84875.1 Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes
10.7554/eLife.87202.1 Detecting and validating influential organisms for rice growth: An ecological network approach
10.7554/eLife.86823.1 Plasticity of gene expression in the nervous system by exposure to environmental odorants that inhibit HDACs
10.7554/eLife.86824.1 Intercellular Communication Compensates Intracellular Proliferative Signal Deficit during Liver Regeneration
10.7554/eLife.87281.1 CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment
10.7554/eLife.85562.1 Steroidogenesis and androgen/estrogen signaling pathways are altered in in vitro matured testicular tissues of prepubertal mice
10.7554/eLife.86784.1 Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism
10.7554/eLife.86669.1 ZMYM2 controls transposable element transcription through distinct co-regulatory complexes
10.7554/eLife.86847.1 Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery
10.7554/eLife.87135.1 Tetraose steroidal glycoalkaloids from potato can provide complete protection against fungi and insects
10.7554/eLife.87253.1 Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A
10.7554/eLife.86635.1 Adolescent length growth spurts in bonobos and other primates: Mind the scale
10.7554/eLife.86617.1 A billion years arms-race between viruses, virophages and eukaryotes
10.7554/eLife.86670.1 Transcriptomic profiling of tissue environments critical for post-embryonic patterning and morphogenesis of zebrafish skin
10.7554/eLife.86577.1 A dynamic bactofilin cytoskeleton recruits an M23 endopeptidase to control bacterial morphogenesis
10.7554/eLife.87147.1 Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms
10.7554/eLife.86016.1 Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM
10.7554/eLife.85795.1 Temperature sensitivity of the interspecific interaction strength of coastal marine fish communities
10.7554/eLife.86976.1 The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery
10.7554/eLife.86464.1 Courtship behaviour reveals temporal regularity is a critical social cue in mouse communication
10.7554/eLife.86845.1 Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse
10.7554/eLife.86700.1 Drosophila macrophages control systemic cytokine levels in response to oxidative stress via a non-canonical DNA damage repair signaling cascade
10.7554/eLife.86507.1 Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration
10.7554/eLife.87146.1 A tRNA modification in Mycobacterium tuberculosis facilitates optimal intracellular growth
10.7554/eLife.86727.1 Calcium transients trigger switch-like discharge of prostaglandin E2 (PGE2) in an ERK-dependent manner
10.7554/eLife.85597.1 Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor
10.7554/eLife.87167.1 Energy Coupling and Stoichiometry of Zn2+/H+ Antiport by the Cation Diffusion Facilitator YiiP
10.7554/eLife.87042.1 Striatal ensemble activity in an innate naturalistic behavior
10.7554/eLife.87039.1 Linking genotypic and phenotypic changes in the LTEE using metabolomics
10.7554/eLife.87026.1 Extensive re-modelling of the cell wall during the development of Staphylococcus aureus bacteraemia
10.7554/eLife.86689.1 CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis
10.7554/eLife.87178.1 Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange